A threshold delay model of HIV infection of newborn infants through breastfeeding.

TitleA threshold delay model of HIV infection of newborn infants through breastfeeding.
Publication TypeJournal Article
Year of Publication2019
AuthorsTeslya A, Qesmi R, Wu J, Heffernan JM
JournalInfectious Disease Modelling
Volume4
Pagination188-214
Date Published2019
ISSN2468-0427
Abstract

The breast milk of HIV infected women contains HIV virus particles, therefore children can become infected through breastfeeding. We develop a mathematical epidemiological model of HIV infection in infants, infected children and infected women that represents infection of an infant/child as a series of exposures, by incorporating within-host virus dynamics in the individuals exposed to the virus through breastfeeding. We show that repeated exposures of the infant/child via breastfeeding can cause bi-stability dynamics and, subsequently, infection persistence even when the epidemiological basic reproduction number is less than unity. This feature of the model, due to a backward bifurcation, gives new insight into the control mechanisms of HIV disease through breastfeeding.

DOI10.1016/j.idm.2019.05.001
Alternate JournalInfect Dis Model