Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host.

TitleModelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host.
Publication TypeJournal Article
Year of Publication2017
AuthorsYan AWC, Cao P, Heffernan JM, McVernon J, Quinn KM, La Gruta NL, Laurie KL, McCaw JM
JournalJournal of theoretical biology
Volume413
Pagination34-49
Date Published2017 Jan 21
ISSN1095-8541
KeywordsAdaptive Immunity, CD8-Positive T-Lymphocytes, Cross Reactions, Epitopes, Host-Pathogen Interactions, Humans, Immunity, Cellular, Immunologic Memory, Influenza, Human, Models, Immunological, Viral Load
Abstract

The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a short timeframe provide insight into the underlying viral dynamics and the role of a cross-reactive immune response in resolving an acute infection. We construct a mathematical model of within-host influenza viral dynamics including three possible factors which determine the strength of the cross-reactive cellular adaptive immune response: the initial naive T cell number, the avidity of the interaction between T cells and the epitopes presented by infected cells, and the epitope abundance per infected cell. Our model explains the experimentally observed shortening of a second infection when cross-reactivity is present, and shows that memory in the cellular adaptive immune response is necessary to protect against a second infection.

DOI10.1016/j.jtbi.2016.11.008
Alternate JournalJ. Theor. Biol.